Labradors Forums banner
21 - 40 of 78 Posts
Helen, a quick 'google' (which is by no means foolproof I know) brought up this information:

The active substance of Suprelorin 4.7 mg implant for dogs is deslorelin (as deslorelin acetate). Deslorelin acts by suppressing the function of the pituitary-gonadal axis when applied in a low, continuous dose. This suppression results in the failure of treated animals to synthesise and/or release follicle stimulating hormone and luteinising hormone, which are responsible for the maintenance of fertility.

Which led me to see what effects are known when you suppress the function of the pituitary-gonadal axis:

Disturbances of the hypothalamic–pituitary–gonadal axis are a frequent cause of sexual dysfunction and have also been associated with depression in males (Schweiger et al., 1999).

That last quote just came up with the search for 'pituitary-gonadal axis' and relates to alcoholism in humans, but if you look through the articles, there seems to be a definite link between depression and suppressing the function of this *bit* of the body. I'd dig a bit more but I've had my tea break, back to the grindstone I'm afraid......
 
Tarimoor_Art said:
...but if you look through the articles, there seems to be a definite link between depression and suppressing the function of this *bit* of the body. I'd dig a bit more but I've had my tea break, back to the grindstone I'm afraid......
Ask any man and I think you'll find that they get depressed just thinking about castration (chemical or not) let alone any effects of having it done :lol: :lol: :lol: :lol: :lol: and dare I add that males often seem to have an increased level of fear of strangers especially people in white. A heighten level of aggression towards people with knives can also be observed :lol: :lol: It all makes perfectly sense now and must be linked to all male creatures on this planet.

Sorry, Helen, just couldn't resist :lol: :lol: :lol:

Natasha
 
In addition to Jo's info he's some info on 'reversal' or rather return of testosterone....

With respect to testosterone levels (an established surrogate marker of fertility), during clinical trials more than 80 % of dogs administered one or more implants, returned to normal plasma testosterone levels (≥0.4 ng/ml) within 12 months of implantation. Ninety-eight percent of dogs returned to normalplasma testosterone levels within 18 months of implantation. However, data demonstrating the complete reversibility of clinical effects (reduced testicular size, reduced ejaculation volume, reduced sperm count and reduced libido) including fertility after six months, or repeated implantation, are limited.
During clinical trials, most of the smaller size dogs (<10 kg) maintained suppressed levels of testosterone for more than 12 months following implantation. For very large dogs (>40 kg), data are limited but duration of testosterone suppression was comparable to that seen in medium and large dogs. The use of the product in dogs of less than 10 kg or more than 40 kg bodyweight, therefore, should be subject to a risk/benefit assessment performed by the veterinarian.

from http://www.noahcompendium.co.uk/Virbac_Limited/Suprelorin_4_7_mg_implant_for_dogs/-48969.html

There's not much mentioned under adverse reactions but as your vet was so quick to acknowledge the issue perhaps he will report it (there's a special form they submit for prescription based meds)
 
Discussion starter · #25 ·
Thank you Joanne that is HUGELY interesting and will go and investigate further now. And thank you also Sarah for the info above - am slightly concerned about the time frames.... and a HUGE thank you to you Natasha for giving me the only giggle I've had today :wink:

I am now hugely stressed and distressed that anyone on here or reading this *may* think my dogs' behaviour is anything other than what I have written about ie. a reaction to an implant. I take your points above Jules and with the greatest respect, but I don't want them on this thread if at all possible as it is just NOT applicable in this case. But I also don't want you to think I am upset with you for raising them etc :wink: I just don't want any further discussion on this thread about it if possible, another thread fine - :flower:

Wylye IS a lovely, lovely boy. He is, as many of you here will understand being fellow dog lovers, pretty much the centre of my universe and it is HORRIBLE to see things go so badly wrong. It is NO fault of his but sadly all mine and the decisions I have made along the way. I very much hope in time I can rectify it all and once again I will have my happy, shiney and confident boy back. God help me if I can't as I will then have to live with the choices I made, and that is very very sad for me and him especially, and not forgetting the person who bred him and did so with such love and care.....
 
Helen - we all make decisions for the best of reasons with the information we have available at the time - beating yourself up, for what appeared to be a wise choice at the time you made it, will not help (though we are all partial to it). Onwards & upwards to Wylye finding his feet again.

Let me give another example - I had Zadie's cataract operated on which lead to a 3 month recovery period that was grim for Zoods, followed a few months later by her getting posterior capsule opacification (basically the eye looks completely cloudy again). From what I've read subsequently, her cataract may never have progressed. So should we have had the op done - who knows? But we did and regret won't change anything - and maybe it was the right decision anyway.

Really hope removal of the implant has a speedy impact and you get you confident, happy boy back asap
 
I'm sorry to hear about Wylie. :( I hope once the implant is removed he returns to his "old self".

I understand first hand that feeling of thinking we've made the wrong decision for our dogs. As you know, I had Leo neutered for my own selfish reasons and from that day onwards (2 years ago now) we haven't been able to have Daisy and Leo in the same room as each other. :( I frequently beat myself up over it but we aren't to know what could happen.



Vicki
 
barney2007 said:
I take your points above Jules and with the greatest respect, but I don't want them on this thread if at all possible as it is just NOT applicable in this case.
It's no problem Helen. I just felt I needed to justify why said what I said, otherwise it looked like I'd made it up. I have no reason to want to cause trouble and that certainly wasn't my intention. I just hope your lovely Wylye is back to his old self very soon and I'll bail out of this thread now :) .
 
I remember your previous thread on whether to castrate or not and going down the implant route I found all the information very interesting and being in your situation with what you wanted for Wylie, the implant sounded like the best choice.

Try not to beat yourself up on the decisions made as they were clearly done in the best of intentions :)

Im sure Wylie will be back to his old self in time.
 
So sorry to hear about the changes in Wylye.

I have always been wary about castration full stop after I had my German Shepherd done. As far as I am concerned it 'ruined' my lovely dog :( He suffered terribly from fear aggression afterwards and became really aggresive with strangers. I had to have him put down when he was 6 years old as he bit one of my children's friends. Sadly that wasn't his first bite but it was the first child. I knew both his sire and dam and they were both good natured dogs and since he was such a softie before his op I am sure it was the castration that caused his problems and definitely not his breeding.

Despite his problems I did decide to have Ben castrated and although he hasn't become aggressive I haven't really seen that many advantages. He doesn't chase bitches in season or scent mark but he can still be a sex pest with bitches when he meets them. He has also become more laid back and food obsessive and since he has elbow problems this is not good!

For all of the above reasons I am definitely going to leave Logie entire. He is not the most confident of dogs and therefore I have always worried he might suffer from fear aggresion if he was done. He is generally very good and is quite a gentleman with bitches and only humps Ben occasionally :wink:

A few months ago I think all the bitches in our village were in season at once and he became a right escape artist and it was a total nightmare. I did consider castration but then decided against it and we built a run for him instead. Of course since it was built he hasn't shown any inclination to wander but I think all them ladies will be coming into season again so it will be used.

Hopefully Wylye will be back to normal self again when the effects have worn off.

Eileen
 
Sorry Helen haven't read the whole thread but just wanted to wish you luck for the removal and will keep everything crossed that you get "your boy" back.

Thinking of you

Katy
 
very sorry to hear about poor wyle.
I had a very similar situation with billy my cocker and went down the suprelorin route and he ended up alot worse with aggression towards nearly all dogs he didn't know, thankfully not as extreme as wyle but still terrible upsetting. It's been 2 years since he had the implant and it's only worn off completely in the last couple of months, but he is a small dog and although i was told it would last longer in smaller dogs, i wasn't expecting it to be that long,
Thankfully since it's worn off billy has reverted back to how he was prior to the implant so there is hope that wyle will also,
I know 3 others who have had the implant with no effect at all on their behaviour, one was even alot better for having it so i guess it does work for some.
Good luck with having it removed. Please let us know how he gets on x
 
You know we send our love and support in any way we can in helping to return Wylye to a happy, socially relaxed, boy again. I do agree completely that our dogs are all products of many things, definately their parentage, absolutely their life experiences and of course their 'raising', and you know we will give you as much support as poss in clearing up any after effects that may still linger after the removal.

I wonder if he would have responded the same way if he had been physcially castrated? The chemical alternative seemed such a good idea at the time to all of us didn't it H!? As a half way house.... :-( I know this experience has made me cautious of suggesting it again (as I have many times in the past to people who were hesitant about actual castration...)

But just to add I do know a number of people who have used it to good effect, and also dozens, maybe hundreds for whom physcial castration has been a very non stressful and routine proceedure and recovery (including my own dogs I have castrated and its always my advice to buyers to castrate a pet dog unless they have a blinding reason not to...), so noone be put off these responsible acts through one or two negative experiences. Like anything, I am certain these bad reactions are in the minority.

Hugs Hun and hope its all 'up' from here.

Di xx
 
Discussion starter · #35 ·
AlfiesMum said:
went down the suprelorin route and he ended up alot worse with aggression towards nearly all dogs he didn't know, thankfully not as extreme as wyle but still terrible upsetting. It's been 2 years since he had the implant and it's only worn off completely in the last couple of months,
Godoness TWO YEARS!!! I am hoping that the fact that he has only had it in 3 months and that they are removing it completely (as I write even), that the recovery will be much, much quicker than that. This morning they did point out that they couldn't give me any sort of time frame as it is 'unknown'. I'm sorry to read it wasn't a great success for you either but very nice to read that things got better :)

Di, thank you. You are right in that the majoirty of dogs have had no ill effects from this implant and in fact if anything it has had a positive effect on behaviour. I guess the trouble with drugs is that they are never 100% and there is always those that will and do have a bad reaction to them. From a personal point of view I would NEVER consider this implant again but then I have been I guess very unlucky.

I think I am highly unlikely to get Wylye surgically neutered now, if only because I don't want to *mess* with him anymore if that makes sense. This is quite a hard decision from someone like me who is so PRO neutering and remains so BUT just not for my boy :wink:

I am glad people have found the thread interesting/of use. It is why I posted it in the first place.

Thanks a million for all your support. GREATLY appreciated :flower:


PS. Boot75, your dog, the black one, in your signature is gorgeous.
 
barney2007 said:
I guess the trouble with drugs is that they are never 100% and there is always those that will and do have a bad reaction to them. From a personal point of view I would NEVER consider this implant again but then I have been I guess very unlucky.
I do wonder whether the injection would have the same effect as the implant. I understand the chemical castration injection lasts 6 weeks (I can't remember what it is called) but I don't know if it works in the same way as the implant? I discussed it with a behaviourist before.
 
Discussion starter · #37 ·
No idea on the injection front, maybe someone else on here can help?

I wrote to the manufacturers of Suprelorin and have received this. I hope the UK contact gets in touch soon:



Dear Helen,

Thank you for your e-mail to Peptech and notifying us of your concerns regarding the Suprelorin implant.

Within the UK the product is registered to Virbac and hence I have forwarded your e-mail onto the relevant contact who will contact you shortly to discuss your case.

Kind regards,

Katie

Katie Yeates
Manager, Marketing and Technical Services
Peptech Animal Health
 
Sorry to read your post Helen, hoped that things may have worked out better but at least you have been able to get the implant removed . Thankyou for posting as I am not up on the implications of the chemical casteration route and thought it might have been useful to help make a decision as to whether casteration would be beneficial or not. Question now is was it a reaction to the chemicals or to the suppression of testosterone ?

I suppose that I am not pro neutering for every dog as I do think that it can cause major issues in the nervous less confident dogs but it does seem to help others so maybe I am with the ' take each case individually and then decide ' view.
 
Helen, if you are interested in reporting it as an adverse reaction, this is the form I mentioned earlier.

I reported Basils reaction to metoclopramide a couple of years back.

I didn't get much of a response tbh but I personally believe it's still right to raise your hand and be counted. That way, at the very least, it will be documented as an adverse reaction on the drug info when enough people make them aware.


http://www.vmd.gov.uk/
 
barney2007 said:
will confirm that the dog I am describing is VERY different to the dog they know from their past interactions with him.
Okay, so I know I never saw Wylye as much as Ange or Becs, but we did see him all winter last year on the shoot, and Oz & Gus spent time with him last year - and that's why it was such a surprise to see you recently and have him take a dislike to Gus - it was really unexpected and seemed very out of character for the "old" Wylye that we hung out with last winter.

I'm so sorry he's changed so much, and I really hope that removal of the implant today gets him back to his old self soon.

I know it's different as I'm human and it's blocking different hormones, but previously I have had a hormonal implant myself for just 4 months, it was giving me migranes so I had them remove it - and it took 2 years for my hormones to "right" themselves again... I really hope that it doesn't take as long in Wylye's case. Also, good luck with the behaviourist, I hope he/she can give you some reassurance and some coping mechanisms/strategies for situations which worry poor old W :(

Loads of hugs, hope your boy is home with you by now and not too sleepy from the GA today xoxoxo
 
21 - 40 of 78 Posts