Calling owners of labs with severe HD - your breed needs YOU

mrsm · Posted: Sun Jul 06, 2008 12:55 pm Post subject:

Sue will ask Di and be back Wink

mrsm · Posted: Sun Jul 06, 2008 1:12 pm Post subject:

Have emailed to ask about posting to them.................let you know what they say.

Di says one of two ways by airmail in a jiffy bag or fedex which is more expensive but guaranteed Wink

sue51 · Posted: Sun Jul 06, 2008 6:26 pm Post subject:

sue51 · Posted: Mon Jul 07, 2008 7:19 pm Post subject:

Bumping again for anyone who may have missed this.

JulesXX · Posted: Fri Sep 19, 2008 12:16 am Post subject:

EvelynH · Posted: Fri Sep 19, 2008 6:35 am Post subject:

this test will say if the pup is carrying the gene that might make develope hd, but you don´t know if they really develope it, until you x ray them.

so a breeder tests all his puppies, keeps for himself the one with the good gene.

and the pup still can pass the hd, and what happens with the others....
for me it sound like frankenstein Shocked

sue51 · Posted: Fri Sep 19, 2008 6:51 am Post subject:

EvelynH · Posted: Fri Sep 19, 2008 7:47 am Post subject:

google translated. it must be in english anywhere, but can not find it

"The Hüftgelenksdysplasie of the dog (HD) is a common, hereditary
Developmental disorder of the hip joint. HD is the subluxation of the
Femoral head and deformation of the hip and characterized pan
leads to painful osteoarthritis. Analysis of inheritance have shown that
when a German shepherd at the main expression of the HD involved
is. It was a scan of the entire genome to "quantitative trait loci"
(quantitative characteristics locus, QTL) at the German shepherd
performed. These were found 11 paternal Halbgeschwisterfamilien
examines the total 459 purebred German Shepherds included,
Father with 11 animals and the mother animals and the offspring. All dogs
carry 261 were genotyped micro-satellites. These markers were
spread evenly over All 38 autosomes and the X-chromosome distributed, with a
middle distance of 11.7 cM (= CENTI-Morgan). The mean observed
Heterozygosität sets of markers was 50%. The HD status of the dogs was
after the official FCI rules. With a genome-wide
Significance of p <0.05 were the QTLs for HD on nine different
Dogs localized chromosomes: 1, 3, 4, 8, 9, 16, 19, 26 and 33 The
minimal QTL regions, the HD genes involved, was carried out over
an average of 5 MB (mega-bases), with a fluctuation between 1 and
About 8.2 Mb seen all the chromosomes were treated with a significance of
p <0.05 QTLs to 19 chromosomes found. Further analysis can now
be mapped to these positions at the QTLs
German shepherd accurate mapping. "

The work was written by Yvonne Marshall and drafted Distler Ottmar
and is in "Mammalian Genome" (2007) 18: 861-870 published.